Digital pathology slide viewing and annotation
A single slide scanned at diagnostic resolution can run to several gigabytes, and a pathologist needs to move across it, zoom from the whole tissue section to individual cells, and back, without waiting. Daily use of the platform depends on the viewer.
How large images are served
Whole slide images are stored as pyramids. The full resolution image is accompanied by smaller versions, each divided into tiles. The viewer requests tiles for the region and zoom level on screen, allowing users to pan and zoom through very large images.
The engineering is in tile serving, caching, prefetching the tiles the pathologist is likely to want next, and doing it over networks that are not always fast.
Every scanner vendor has historically had its own format, and DICOM whole slide imaging is the emerging standard for interoperability.
A viewer that reads multiple formats natively, or that ingests them into a common internal representation, spares the lab a conversion step on every slide.
Annotation
Pathologists annotate. They outline a tumor region, mark a suspicious area for a colleague, flag an artifact to exclude from analysis, and record a score. Annotation tools need to be fast enough to keep up with a trained hand and structured enough that the annotations are usable downstream, as training data for models, as the regions a quantification pipeline runs on, as a record in the case file.
With layers, so different annotators or different purposes stay separated.
Scoring capture and review
The viewer is also where scores are entered and reviewed. A well built platform presents the computational score alongside the region it was calculated from, lets the pathologist confirm, adjust, or override, and records who decided what and when.
That audit trail matters clinically and matters for any regulatory context the results feed into.
Integration
A viewer that is disconnected from the rest of the system creates extra work. It needs integration with the laboratory information system, so a case opens with its slides and metadata already attached, and with reporting, so a signed score flows into the report.
SequoiaAT delivered a fast viewer within its digital pathology platform that lets pathologists zoom, annotate, and score samples in real time, alongside automated slide scoring and validation in the pipeline behind it.
Read the case study →